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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">AP-1</span></h1>
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<p><b>AP-1</b> ist ein <a href="Transkriptionsfaktor" title="Transkriptionsfaktor">Transkriptionsfaktor</a>. AP-1 ist ein <a href="Heterodimer" class="mw-redirect" title="Heterodimer">heterodimerer</a> <a href="Proteinkomplex" title="Proteinkomplex">Proteinkomplex</a> aus Proteinen der Familien <a href="ATF" class="mw-disambig" title="ATF">ATF</a>, <a href="JDP" class="mw-disambig" title="JDP">JDP</a>, <a href="C-Fos" title="C-Fos">c-Fos</a> und <a href="C-Jun" title="C-Jun">c-Jun</a> und <a href="DNA-Protein-Interaktion" class="mw-redirect" title="DNA-Protein-Interaktion">bindet</a> als Dimer an <a href="DNA" class="mw-redirect" title="DNA">DNA</a>, um die <a href="Transkription_(Biologie)" title="Transkription (Biologie)">Transkription</a> bestimmter <a href="Gen" title="Gen">Gene</a> einzuleiten.
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<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p>Die von AP-1 regulierten Gene umfassen Gene der <a href="Zelldifferenzierung" class="mw-redirect" title="Zelldifferenzierung">Zelldifferenzierung</a>, der <a href="Zellteilung" title="Zellteilung">Zellteilung</a> und der <a href="Apoptose" title="Apoptose">Apoptose</a>.<sup id="cite_ref-pmid14585541_1-0" class="reference"><a href="#cite_note-pmid14585541-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Die <a href="Genexpression" title="Genexpression">Genexpression</a> des AP-1 selbst wird durch <a href="Zytokin" title="Zytokin">Zytokine</a>, <a href="Wachstumsfaktor_(Protein)" title="Wachstumsfaktor (Protein)">Wachstumsfaktoren</a>, <a href="Infektion" title="Infektion">Infektionen</a> und <a href="Stressfaktor" class="mw-redirect" title="Stressfaktor">Stressfaktoren</a> induziert.<sup id="cite_ref-pmid15564374_2-0" class="reference"><a href="#cite_note-pmid15564374-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> AP-1 bindet an die DNA über basische <a href="Aminos%C3%A4uren" title="Aminosäuren">Aminosäuren</a>, während die <a href="Dimerisierung" title="Dimerisierung">Dimerisierung</a> durch einen <a href="Leucin-Zipper" class="mw-redirect" title="Leucin-Zipper">Leucin-Zipper</a> vermittelt wird.<sup id="cite_ref-pmid7816143_3-0" class="reference"><a href="#cite_note-pmid7816143-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> AP-1 verstärkt die Genexpression am <i>12-O-Tetradecanoylphorbol-13-acetate DNA response element</i> (<i>TRE</i>, Sequenz 5'-TGAG/CTCA-3').<sup id="cite_ref-pmid15564374_2-1" class="reference"><a href="#cite_note-pmid15564374-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-pmid14585541-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid14585541_1-0">↑</a></span> <span class="reference-text">Ameyar M, Wisniewska M, Weitzman JB: <cite style="font-style:italic">A role for AP-1 in apoptosis: the case for and against</cite>. In: <cite style="font-style:italic">Biochimie</cite>. 85. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>8</span>, August 2003, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>747–52</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.biochi.2003.09.006">10.1016/j.biochi.2003.09.006</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/14585541?dopt=Abstract">PMID 14585541</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:AP-1&rft.atitle=A+role+for+AP-1+in+apoptosis%3A+the+case+for+and+against&rft.au=Ameyar+M%2C+Wisniewska+M%2C+Weitzman+JB&rft.date=2003-08&rft.doi=10.1016%2Fj.biochi.2003.09.006&rft.genre=journal&rft.issue=8&rft.jtitle=Biochimie&rft.pages=747-52&rft.pmid=14585541&rft.volume=85.+Jahrgang" style="display:none"> </span></span>
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<li id="cite_note-pmid15564374-2"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-pmid15564374_2-0">a</a></sup> <sup><a href="#cite_ref-pmid15564374_2-1">b</a></sup></span> <span class="reference-text">Hess J, Angel P, Schorpp-Kistner M: <cite style="font-style:italic">AP-1 subunits: quarrel and harmony among siblings</cite>. In: <cite style="font-style:italic">J. Cell. Sci.</cite> 117. Jahrgang, Pt 25, 2004, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>5965–73</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1242/jcs.01589">10.1242/jcs.01589</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/15564374?dopt=Abstract">PMID 15564374</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:AP-1&rft.atitle=AP-1+subunits%3A+quarrel+and+harmony+among+siblings&rft.au=Hess+J%2C+Angel+P%2C+Schorpp-Kistner+M&rft.date=2004&rft.doi=10.1242%2Fjcs.01589&rft.genre=journal&rft.issue=Pt+25&rft.jtitle=J.+Cell.+Sci.&rft.pages=5965-73&rft.pmid=15564374&rft.volume=117.+Jahrgang" style="display:none"> </span></span>
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<li id="cite_note-pmid7816143-3"><span class="mw-cite-backlink"><a href="#cite_ref-pmid7816143_3-0">↑</a></span> <span class="reference-text">Glover JN, Harrison SC: <cite style="font-style:italic">Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA</cite>. In: <cite style="font-style:italic"><a href="Nature" title="Nature">Nature</a></cite>. 373. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>6511</span>, 1995, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>257–61</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1038/373257a0">10.1038/373257a0</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/7816143?dopt=Abstract">PMID 7816143</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:AP-1&rft.atitle=Crystal+structure+of+the+heterodimeric+bZIP+transcription+factor+c-Fos-c-Jun+bound+to+DNA&rft.au=Glover+JN%2C+Harrison+SC&rft.date=1995&rft.doi=10.1038%2F373257a0&rft.genre=journal&rft.issue=6511&rft.jtitle=Nature&rft.pages=257-61&rft.pmid=7816143&rft.volume=373.+Jahrgang" style="display:none"> </span></span>
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